Inhibitory Peptide of Mitochondrial μ-Calpain Protects against Photoreceptor Degeneration in Rhodopsin Transgenic S334ter and P23H Rats

Mitochondrial μ-calpain and apoptosis-inducing factor (AIF)-dependent photoreceptor cell death has been seen in several rat and mouse models of retinitis pigmentosa (RP). Previously, we demonstrated that the specific peptide inhibitor of mitochondrial μ-calpain, Tat-µCL, protected against retinal de...

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Autors principals: Ozaki, Taku, Ishiguro, Sei-ichi, Hirano, Satoshi, Baba, Ayaka, Yamashita, Tetsuro, Tomita, Hiroshi, Nakazawa, Mitsuru
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739725/
https://ncbi.nlm.nih.gov/pubmed/23951212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071650
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