Activation of Guanylate Cyclase-C Attenuates Stretch Responses and Sensitization of Mouse Colorectal Afferents

Irritable bowel syndrome (IBS) is characterized by altered bowel habits, persistent pain and discomfort, and typically colorectal hypersensitivity. Linaclotide, a peripherally restricted 14 aa peptide approved for the treatment of IBS with constipation, relieves constipation and reduces IBS-associat...

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Main Authors: Feng, Bin, Kiyatkin, Michael E., La, Jun-Ho, Ge, Pei, Solinga, Robert, Silos-Santiago, Inmaculada, Gebhart, Gerald F.
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2013
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739058/
https://ncbi.nlm.nih.gov/pubmed/23739979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5114-12.2013
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