LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

Reactivation of fetal hemoglobin (HbF) holds therapeutic potential for sickle cell disease and β-thalassemias. In human erythroid cells and hematopoietic organs, LIN28B and its targeted let-7 microRNA family, demonstrate regulated expression during the fetal-to-adult developmental transition. To exp...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Y. Terry, de Vasconcellos, Jaira F., Yuan, Joan, Byrnes, Colleen, Noh, Seung-Jae, Meier, Emily R., Kim, Ki Soon, Rabel, Antoinette, Kaushal, Megha, Muljo, Stefan A., Miller, Jeffery L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2013
Ämnen:
Red Cells, Iron, and Erythropoiesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739030/
https://ncbi.nlm.nih.gov/pubmed/23798711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-472308
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