Lung Cancer Cells That Survive Ionizing Radiation Show Increased Integrin α2β1- and EGFR-Dependent Invasiveness

Ionizing radiation (IR)-enhanced tumor invasiveness is emerging as a contributor to the limited benefit of radiotherapy; however, its mechanism is still unclear. We previously showed that subcloned lung adenocarcinoma A549 cells (P cells), which survived 10 Gy IR (IR cells), acquired high invasivene...

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Bibliographic Details
Main Authors: Li, Xue, Ishihara, Seiichiro, Yasuda, Motoaki, Nishioka, Takeshi, Mizutani, Takeomi, Ishikawa, Masayori, Kawabata, Kazushige, Shirato, Hiroki, Haga, Hisashi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738636/
https://ncbi.nlm.nih.gov/pubmed/23951036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070905
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