GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm

Genome-wide association studies (GWAS) yielded significant advances in defining the genetic architecture of complex traits and disease. Still, a major hurdle of GWAS is narrowing down multiple genetic associations to a few causal variants for functional studies. This becomes critical in multi-phenot...

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Detalhes bibliográficos
Main Authors: Bottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagné, Raphaële, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, François, Nordestgaard, Børge G., Fumeron, Fredéric, Tybjærg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence, Richardson, Sylvia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738451/
https://ncbi.nlm.nih.gov/pubmed/23950726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003657
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