GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm

Genome-wide association studies (GWAS) yielded significant advances in defining the genetic architecture of complex traits and disease. Still, a major hurdle of GWAS is narrowing down multiple genetic associations to a few causal variants for functional studies. This becomes critical in multi-phenot...

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主要な著者: Bottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagné, Raphaële, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, François, Nordestgaard, Børge G., Fumeron, Fredéric, Tybjærg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence, Richardson, Sylvia
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738451/
https://ncbi.nlm.nih.gov/pubmed/23950726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003657
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