Evolutionary Pathways in BRCA1-Associated Breast Tumors

BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations of PTEN and TP53. Here we describe the analysis of BRCA1, PTEN, and p53 at the single cell level in 55 BRCA1-associated breast tumors and computational methods to predict the relative temporal order of somatic events...

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Huvudupphovsmän: Martins, Filipe C., De, Subhajyoti, Almendro, Vanessa, Gönen, Mithat, Park, So Yeon, Blum, Joanne L., Herlihy, William, Ethington, Gabrielle, Schnitt, Stuart J., Tung, Nadine, Garber, Judy E., Fetten, Katharina, Michor, Franziska, Polyak, Kornelia
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738298/
https://ncbi.nlm.nih.gov/pubmed/22628410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0325
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