Evolutionary Pathways in BRCA1-Associated Breast Tumors

BRCA1-associated breast tumors display loss of BRCA1 and frequent somatic mutations of PTEN and TP53. Here we describe the analysis of BRCA1, PTEN, and p53 at the single cell level in 55 BRCA1-associated breast tumors and computational methods to predict the relative temporal order of somatic events...

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Detalhes bibliográficos
Main Authors: Martins, Filipe C., De, Subhajyoti, Almendro, Vanessa, Gönen, Mithat, Park, So Yeon, Blum, Joanne L., Herlihy, William, Ethington, Gabrielle, Schnitt, Stuart J., Tung, Nadine, Garber, Judy E., Fetten, Katharina, Michor, Franziska, Polyak, Kornelia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738298/
https://ncbi.nlm.nih.gov/pubmed/22628410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0325
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