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Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
Intratumor genetic heterogeneity is a key mechanism underlying tumor progression and therapeutic resistance. The prevailing model for explaining intratumor diversity, the clonal evolution model, has recently been challenged by proponents of the cancer stem cell hypothesis. To investigate this issue,...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2810089/ https://ncbi.nlm.nih.gov/pubmed/20101094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40724 |
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