While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIδ-KO mice

OBJECTIVE: CaMKII contributes to impaired contractility in heart failure by inducing SR Ca(2+)-leak. CaMKII-inhibition in the heart was suggested to be a novel therapeutic principle. Different CaMKII isoforms exist. Specifically targeting CaMKIIδ, the dominant isoform in the heart, could be of thera...

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Main Authors: Neef, Stefan, Sag, Can M., Daut, Maria, Bäumer, Henrik, Grefe, Clemens, El-Armouche, Ali, DeSantiago, Jaime, Pereira, Laetitia, Bers, Donald M., Backs, Johannes, Maier, Lars S.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738196/
https://ncbi.nlm.nih.gov/pubmed/23473775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2013.02.014
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