CRISPR-Cas systems preferentially target the leading regions of MOB(F) conjugative plasmids

Most prokaryotes contain CRISPR-Cas immune systems that provide protection against mobile genetic elements. We have focused on the ability of CRISPR-Cas to block plasmid conjugation, and analyzed the position of target sequences (protospacers) on conjugative plasmids. The analysis reveals that proto...

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Detalhes bibliográficos
Main Authors: Westra, Edze R., Staals, Raymond H.J., Gort, Gerrit, Høgh, Søren, Neumann, Sarah, de la Cruz, Fernando, Fineran, Peter C., Brouns, Stan J.J.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737333/
https://ncbi.nlm.nih.gov/pubmed/23535265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.24202
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