Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation

In enteric bacteria, the kinase LsrK catalyzes the phosphorylation of the C5-hydroxyl group in the linear form of 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of the type II bacterial quorum sensing molecule (AI-2). This phosphorylation is required for AI-2 sequestration in the cytoplasm and...

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Bibliografiske detaljer
Main Authors: Zhu, Jie, Hixon, Mark S., Globisch, Daniel, Kaufmann, Gunnar F., Janda, Kim D.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736694/
https://ncbi.nlm.nih.gov/pubmed/23672516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4024989
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