Age Associated Increase of Low Avidity CMV-Specific CD8(+) T Cells That Re-Express CD45RA

The mechanisms regulating memory CD8(+) T cell function and homeostasis during ageing are unclear. CD8(+) effector memory T cells that re-express CD45RA (EMRA T cells) increase considerably in older humans and both ageing and persistent cytomegalovirus (CMV) infection are independent factors in this...

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Detalhes bibliográficos
Main Authors: Griffiths, Stephen J., Riddell, Natalie E., Masters, Joanne, Libri, Valentina, Henson, Sian M., Wertheimer, Anne, Wallace, Diana, Sims, Stuart, Rivino, Laura, Larbi, Anis, Kemeny, David M., Nikolich-Zugich, Janko, Kern, Florian, Klenerman, Paul, Emery, Vince C., Akbar, Arne N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736312/
https://ncbi.nlm.nih.gov/pubmed/23636061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203267
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