Supplemental Dietary Folic Acid Has No Effect on Chromosome Damage in Erythrocyte Progenitor Cells of Mice(2)

Folate deficiency can cause chromosome damage, which could result from reduced de novo thymidylate synthesis or DNA hypomethylation. High folic acid intake has been hypothesized to inhibit folate-dependent one-carbon metabolism, which could also lead to DNA damage. A large proportion of the general...

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Autors principals: Swayne, Breanne G., Behan, Nathalie A., Williams, Andrew, Stover, Patrick J., Yauk, Carole L., MacFarlane, Amanda J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Nutrition 2012
Matèries:
Biochemical, Molecular, and Genetic Mechanisms
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735919/
https://ncbi.nlm.nih.gov/pubmed/22437555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3945/jn.112.157750
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