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A critical context-dependent role for E boxes in the targeting of somatic hypermutation
Secondary B cell repertoire diversification occurs by somatic hypermutation (SHM) in germinal centers following antigen stimulation. In SHM, activation-induced cytidine deaminase (AID) mutates the variable region of the immunoglobulin (Ig) genes to increase the affinity of antibodies. Although somat...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3735716/ https://ncbi.nlm.nih.gov/pubmed/23836058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300969 |
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