Structural Integrity of the Greek Key Motif in βγ-Crystallins Is Vital for Central Eye Lens Transparency

BACKGROUND: We highlight an unrecognized physiological role for the Greek key motif, an evolutionarily conserved super-secondary structural topology of the βγ-crystallins. These proteins constitute the bulk of the human eye lens, packed at very high concentrations in a compact, globular, short-range...

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Библиографические подробности
Главные авторы: Vendra, Venkata Pulla Rao, Agarwal, Garima, Chandani, Sushil, Talla, Venu, Srinivasan, Narayanaswamy, Balasubramanian, Dorairajan
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735602/
https://ncbi.nlm.nih.gov/pubmed/23936409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070336
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