Structural analysis of the mutant protein D26G of human γS-crystallin, associated with Coppock cataract

PURPOSE: To analyze the protein structural features responsible for the aggregation properties of the mutant protein D26G human γS-crystallin (HGSC) associated with congenital Coppock-type cataract. METHODS: cDNAs of wild-type (WT) and D26G mutant HGSC were cloned and expressed in BL21 (DE3) pLysS c...

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Main Authors: Karri, Srinivasu, Kasetti, Ramesh Babu, Vendra, Venkata Pulla Rao, Chandani, Sushil, Balasubramanian, Dorairajan
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675056/
https://ncbi.nlm.nih.gov/pubmed/23761725
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