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Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells
Post-translational degradation of protein plays an important role in cell life. We employed chimeric molecules (dihydrotestosterone-based proteolysis-targeting chimeric molecule [DHT-PROTAC]) to facilitate androgen receptor (AR) degradation via the ubiquitin–proteasome pathway (UPP) and to investiga...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3735208/ https://ncbi.nlm.nih.gov/pubmed/19050678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aja.2008.26 |
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