Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells

Post-translational degradation of protein plays an important role in cell life. We employed chimeric molecules (dihydrotestosterone-based proteolysis-targeting chimeric molecule [DHT-PROTAC]) to facilitate androgen receptor (AR) degradation via the ubiquitin–proteasome pathway (UPP) and to investiga...

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Autores principales: Tang, Yue-Qing, Han, Bang-Min, Yao, Xin-Quan, Hong, Yan, Wang, Yan, Zhao, Fu-Jun, Yu, Sheng-Qiang, Sun, Xiao-Wen, Xia, Shu-Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2009
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735208/
https://ncbi.nlm.nih.gov/pubmed/19050678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aja.2008.26
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