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Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism

Recombination of evolutionarily unrelated domains is a mechanism often used by evolution to produce variety in soluble proteins. By using a classification of polytopic transmembrane domains into families, we examined integral membrane proteins for evidence of this mechanism. Surprisingly, we found t...

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Bibliografische gegevens
Hoofdauteurs: Liu, Yang, Gerstein, Mark, Engelman, Donald M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC373490/
https://ncbi.nlm.nih.gov/pubmed/14993608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307330101
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