The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells

Apogossypolone (ApoG2), a novel derivative of gossypol, exhibits superior antitumor activity in Bcl-2 transgenic mice, and induces autophagy in several cancer cells. However, the detailed mechanisms are not well known. In the present study, we showed that ApoG2 induced autophagy through Beclin-1- an...

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Autors principals: Cheng, P, Ni, Z, Dai, X, Wang, B, Ding, W, Rae Smith, A, Xu, L, Wu, D, He, F, Lian, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734844/
https://ncbi.nlm.nih.gov/pubmed/23392177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.17
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