Identification of p53 regulators by genome-wide functional analysis

The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a gain-of-function cellular screen was carried out with an arrayed matrix of ≈20,000 cDNAs. Nine genes pr...

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Bibliographic Details
Main Authors: Huang, Qihong, Raya, Angel, DeJesus, Paul, Chao, Sheng-Hao, Quon, Kim C., Caldwell, Jeremy S., Chanda, Sumit K., Izpisua-Belmonte, Juan C., Schultz, Peter G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC373483/
https://ncbi.nlm.nih.gov/pubmed/14990790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308562100
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