Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly a reflection of its synthetic capacity, we measured the levels and activity of γ-glutamylcysteine ligase (GCL), the rate-controlling enzyme in GSH synthesis. With age, both the catalytic (GCLC) and modulat...

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Bibliographic Details
Main Authors: Suh, Jung H., Shenvi, Swapna V., Dixon, Brian M., Liu, Honglei, Jaiswal, Anil K., Liu, Rui-Ming, Hagen, Tory M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC373470/
https://ncbi.nlm.nih.gov/pubmed/14985508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400282101
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