The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP ratio. Essential to activation of AMPK is its phosphorylation at Thr-172 by an upstream kinase, AMPKK, whose ident...

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Bibliographic Details
Main Authors: Shaw, Reuben J., Kosmatka, Monica, Bardeesy, Nabeel, Hurley, Rebecca L., Witters, Lee A., DePinho, Ronald A., Cantley, Lewis C.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC373461/
https://ncbi.nlm.nih.gov/pubmed/14985505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308061100
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