The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–activated protein kinase]. The deletion of LKB1 in the liver of adult mice resulted in a nearly complete loss of AMPK activity. Loss of LKB...

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Bibliographische Detailangaben
Hauptverfasser: Shaw, Reuben J., Lamia, Katja A., Vasquez, Debbie, Koo, Seung-Hoi, Bardeesy, Nabeel, DePinho, Ronald A., Montminy, Marc, Cantley, Lewis C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074427/
https://ncbi.nlm.nih.gov/pubmed/16308421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1120781
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