Class IIa Histone Deacetylases are Hormone-activated regulators of FOXO and Mammalian Glucose Homeostasis

Class IIa histone deacetylases (HDACs) are signal-dependent modulators of transcription with established roles in muscle differentiation and neuronal survival. We show here that in liver, Class IIa HDACs (HDAC4, 5, and 7) are phosphorylated and excluded from the nucleus by AMPK family kinases. In re...

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Autors principals: Mihaylova, Maria M., Vasquez, Debbie S., Ravnskjaer, Kim, Denechaud, Pierre-Damien, Yu, Ruth T., Alvarez, Jacqueline G., Downes, Michael, Evans, Ronald M., Montminy, Marc, Shaw, Reuben J.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117637/
https://ncbi.nlm.nih.gov/pubmed/21565617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.043
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