Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan

BACKGROUND: The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chen, Wang-Qing, Shu, Yan, Li, Qing, Xu, Lin-Yong, Roederer, Mary W., Fan, Lan, Wu, Lan-Xiang, He, Fa-Zhong, Luo, Jian-Quan, Tan, Zhi-Rong, He, Yi-Jing, Zhou, Hong-Hao, Chen, Xiang, Zhang, Wei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734062/
https://ncbi.nlm.nih.gov/pubmed/23940561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070341
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