Polymorphism of ORM1 Is Associated with the Pharmacokinetics of Telmisartan

BACKGROUND: The pharmacokinetics (PKs) and pharmacodynamics (PDs) of telmisartan varies among the individuals, and the main causes remain unknown. The aim of this study was to evaluate the impact of ORM1, as well as ABCC2, ABCB1, ABCG2 and SLCO1B3 polymorphisms, on the disposition of the drug and BP...

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Autori principali: Chen, Wang-Qing, Shu, Yan, Li, Qing, Xu, Lin-Yong, Roederer, Mary W., Fan, Lan, Wu, Lan-Xiang, He, Fa-Zhong, Luo, Jian-Quan, Tan, Zhi-Rong, He, Yi-Jing, Zhou, Hong-Hao, Chen, Xiang, Zhang, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734062/
https://ncbi.nlm.nih.gov/pubmed/23940561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070341
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