Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells

Oxythiamine (OT), an analogue of anti-metabolite, can suppress the nonoxidative synthesis of ribose and induce cell apoptosis by causing a G1 phase arrest in vitro and in vivo. However, the molecular mechanism remains unclear yet. In the present study, a quantitative proteomic analysis using the mod...

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Detalhes bibliográficos
Main Authors: Wang, Jiarui, Zhang, Xuemei, Ma, Danjun, Lee, Wai-Nang Paul, Xiao, Jing, Zhao, Yingchun, Go, Vay Liang, Wang, Qi, Yen, Yun, Recker, Robert, Xiao, Gary Guishan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733980/
https://ncbi.nlm.nih.gov/pubmed/23890079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2162-3619-2-18
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