A programmed –1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element

Nonsense-mediated mRNA decay (NMD) directs rapid degradation of premature termination codon (PTC)-containing mRNAs, e.g. those containing frameshift mutations. Many viral mRNAs encode polycistronic messages where programmed –1 ribosomal frameshift (–1 PRF) signals direct ribosomes to synthesize poly...

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Bibliographic Details
Main Authors: Plant, Ewan P., Wang, Pinger, Jacobs, Jonathan L., Dinman, Jonathan D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC373365/
https://ncbi.nlm.nih.gov/pubmed/14762205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh256
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