A programmed –1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element

Nonsense-mediated mRNA decay (NMD) directs rapid degradation of premature termination codon (PTC)-containing mRNAs, e.g. those containing frameshift mutations. Many viral mRNAs encode polycistronic messages where programmed –1 ribosomal frameshift (–1 PRF) signals direct ribosomes to synthesize poly...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Autores principales:	Plant, Ewan P., Wang, Pinger, Jacobs, Jonathan L., Dinman, Jonathan D.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 2004
Materias:	Articles
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC373365/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14762205/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh256
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