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A programmed –1 ribosomal frameshift signal can function as a cis-acting mRNA destabilizing element
Nonsense-mediated mRNA decay (NMD) directs rapid degradation of premature termination codon (PTC)-containing mRNAs, e.g. those containing frameshift mutations. Many viral mRNAs encode polycistronic messages where programmed –1 ribosomal frameshift (–1 PRF) signals direct ribosomes to synthesize poly...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC373365/ https://ncbi.nlm.nih.gov/pubmed/14762205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh256 |
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