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A two-step mechanism for TRF2-mediated chromosome end protection
Mammalian telomeres repress DNA damage activation at natural chromosome ends by recruiting specific inhibitors of the DNA damage machinery that form a protective complex termed shelterin. Within this complex, TRF2 plays a crucial role in end-protection as it is required to suppress ATM activation an...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3733551/ https://ncbi.nlm.nih.gov/pubmed/23389450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11873 |
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