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Loss of asymmetric spine synapses in prefrontal cortex of motor-asymptomatic, dopamine-depleted, cognitively impaired MPTP-treated monkeys

Parkinson's disease is usually characterized as a movement disorder; however cognitive abilities that are dependent on the prefrontal cortex decline at an early stage of the disease in most patients. The changes that underlie cognitive deficits in Parkinson’s disease are not well understood. We...

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Detalhes bibliográficos
Main Authors: Elsworth, John D., Leranth, Csaba, Redmond, D.Eugene, Roth, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733504/
https://ncbi.nlm.nih.gov/pubmed/22947206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145712000892
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