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Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional silencing. Despite its importance, very little is known about how the enzymatic activity and transcript...

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Detalhes bibliográficos
Main Authors: Ling, Yan, Sankpal, Umesh T., Robertson, Andrea K., McNally, James G., Karpova, Tatiana, Robertson, Keith D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC373322/
https://ncbi.nlm.nih.gov/pubmed/14752048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh195
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