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Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional silencing. Despite its importance, very little is known about how the enzymatic activity and transcript...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ling, Yan, Sankpal, Umesh T., Robertson, Andrea K., McNally, James G., Karpova, Tatiana, Robertson, Keith D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2004
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC373322/
https://ncbi.nlm.nih.gov/pubmed/14752048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh195
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