Phase I/II Study of Oncolytic Herpes Simplex Virus NV1020 in Patients with Extensively Pretreated Refractory Colorectal Cancer Metastatic to the Liver

This multicenter phase I/II study evaluated the safety, pharmacokinetics, and antitumor effects of repeated doses of NV1020, a genetically engineered oncolytic herpes simplex virus, in patients with advanced metastatic colorectal cancer (mCRC). Patients with liver-dominant mCRC received four fixed N...

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Detalhes bibliográficos
Main Authors: Geevarghese, Sunil K., Geller, David A., de Haan, Hans A., Hörer, Markus, Knoll, Anette E., Mescheder, Axel, Nemunaitis, John, Reid, Tony R., Sze, Daniel Y., Tanabe, Kenneth K., Tawfik, Hoda
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733135/
https://ncbi.nlm.nih.gov/pubmed/20486770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.020
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