Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice

BACKGROUND: The NV1020 oncolytic herpes simplex virus type-1 has shown significant promise for the treatment of many different types of tumors in experimental animal models and human trials. Previously, we described the construction and use of the NV1020-like virus OncSyn to treat human breast tumor...

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Detalhes bibliográficos
Main Authors: Israyelyan, Anna, Chouljenko, Vladimir N, Baghian, Abolghasem, David, Andrew T, Kearney, Michael T, Kousoulas, Konstantin G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453120/
https://ncbi.nlm.nih.gov/pubmed/18518998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-5-68
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