Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients

First-generation, E1-deleted adenovirus subtype 5 (Ad5)-based vectors, although promising platforms for use as cancer vaccines, are impeded in activity by naturally occurring or induced Ad-specific neutralizing antibodies. Ad5-based vectors with deletions of the E1 and the E2b regions (Ad5 [E1-, E2b...

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Detalhes bibliográficos
Main Authors: Morse, Michael A., Chaudhry, Arvind, Gabitzsch, Elizabeth S., Hobeika, Amy C., Osada, Takuya, Clay, Timothy M., Amalfitano, Andrea, Burnett, Bruce K., Devi, Gayathri R., Hsu, David S., Xu, Younong, Balcaitis, Stephanie, Dua, Rajesh, Nguyen, Susan, Balint, Joseph P., Jones, Frank R., Lyerly, H. Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732790/
https://ncbi.nlm.nih.gov/pubmed/23624851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-013-1400-3
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