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Interspecies Modeling and Prediction of Human Exenatide Pharmacokinetics
PURPOSE: To develop a model-based approach for interspecies scaling of the preclinical pharmacokinetics of exenatide and to predict concentration-time profiles in humans. METHODS: A target-mediated drug disposition (TMDD) model was simultaneously fit to concentration-time profiles of exenatide over...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3732180/ https://ncbi.nlm.nih.gov/pubmed/23229855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0917-z |
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