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Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

Adeno-associated virus (AAV)-based vectors are promising tools for gene therapeutic applications, in part because AAVs are nonpathogenic viruses, and vectors derived from them can drive long-term transgene expression without integration of the vector DNA into the host genome. AAVs are not strongly i...

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Bibliografski detalji
Glavni autori: Jeune, Vedell Louis, Joergensen, Jakob A., Hajjar, Roger J., Weber, Thomas
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732124/
https://ncbi.nlm.nih.gov/pubmed/23442094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2012.243
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