Neutralizing Antibodies Against AAV Serotypes 1, 2, 6, and 9 in Sera of Commonly Used Animal Models

Adeno-associated virus (AAV)-based vectors are promising gene delivery vehicles for human gene transfer. One significant obstacle to AAV-based gene therapy is the high prevalence of neutralizing antibodies in humans. Until now, it was thought that, except for nonhuman primates, pre-existing neutrali...

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Bibliografische gegevens
Hoofdauteurs: Rapti, Kleopatra, Louis-Jeune, Vedell, Kohlbrenner, Erik, Ishikawa, Kiyotake, Ladage, Dennis, Zolotukhin, Sergei, Hajjar, Roger J, Weber, Thomas
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2012
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255603/
https://ncbi.nlm.nih.gov/pubmed/21915102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.177
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