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Plk1 phosphorylation of Orc2 and Hbo1 contributes to gemcitabine resistance in pancreatic cancer

Although gemcitabine is the standard chemotherapeutic drug for treatment of pancreatic cancer, almost all patients eventually develop resistance to this agent. Previous studies identified Polo-like kinase 1 (Plk1) as the mediator of gemcitabine resistance, but the molecular mechanism remains unknown...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Song, Bing, Liu, X. Shawn, Rice, Steven, Kuang, Shihuan, Elzey, Bennett D., Konieczny, Stephen F., Ratliff, Timothy L., Hazbun, Tony, Chiorean, Elena G., Liu, Xiaoqi
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732037/
https://ncbi.nlm.nih.gov/pubmed/23188630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0632
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