Plk1 phosphorylation of Orc2 and Hbo1 contributes to gemcitabine resistance in pancreatic cancer

Although gemcitabine is the standard chemotherapeutic drug for treatment of pancreatic cancer, almost all patients eventually develop resistance to this agent. Previous studies identified Polo-like kinase 1 (Plk1) as the mediator of gemcitabine resistance, but the molecular mechanism remains unknown...

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Main Authors: Song, Bing, Liu, X. Shawn, Rice, Steven, Kuang, Shihuan, Elzey, Bennett D., Konieczny, Stephen F., Ratliff, Timothy L., Hazbun, Tony, Chiorean, Elena G., Liu, Xiaoqi
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732037/
https://ncbi.nlm.nih.gov/pubmed/23188630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0632
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