Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

Treatment with doxorubicin (Dox) results in serious systemic toxicities that limit effectiveness for cancer treatment and cause long-term health issues for cancer patients. We identified a new DNA aptamer to prostate-specific membrane antigen (PSMA) using fixed sequences to promote Dox binding and d...

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Detalhes bibliográficos
Main Authors: Boyacioglu, Olcay, Stuart, Christopher H, Kulik, George, Gmeiner, William H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731884/
https://ncbi.nlm.nih.gov/pubmed/23860551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.37
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