Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content

Sirolimus is an inhibitor of mammalian target of rapamycin (mTOR) and is increasingly being used in transplantation and cancer therapies. Sirolimus has low oral bioavailability and exhibits large pharmacokinetic variability. The underlying mechanisms for this variability have not been explored to a...

詳細記述

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書誌詳細
主要な著者: Emoto, C, Fukuda, T, Cox, S, Christians, U, Vinks, A A
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2013
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731827/
https://ncbi.nlm.nih.gov/pubmed/23884207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.33
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