Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content

Sirolimus is an inhibitor of mammalian target of rapamycin (mTOR) and is increasingly being used in transplantation and cancer therapies. Sirolimus has low oral bioavailability and exhibits large pharmacokinetic variability. The underlying mechanisms for this variability have not been explored to a...

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Bibliografiske detaljer
Main Authors: Emoto, C, Fukuda, T, Cox, S, Christians, U, Vinks, A A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731827/
https://ncbi.nlm.nih.gov/pubmed/23884207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.33
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