High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cirrhotic preneoplastic macronodules (25%) and hepatocellular adenomas with malignant transfor...

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Main Authors: Nault, Jean Charles, Mallet, Maxime, Pilati, Camilla, Calderaro, Julien, Bioulac-Sage, Paulette, Laurent, Christophe, Laurent, Alexis, Cherqui, Daniel, Balabaud, Charles, Rossi, Jessica Zucman
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731665/
https://ncbi.nlm.nih.gov/pubmed/23887712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3218
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