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Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes

Bioreducible polyplexes are promising vectors for delivery of nucleic acids due to low toxicity and favorable transfection activity. The often improved transfection is usually explained by enhanced intracellular reductive disassembly of the polyplexes. This study evaluated the effect of enhanced red...

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Autors principals: Li, Jing, Manickam, Devika S., Chen, Jun, Oupicky, David
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730823/
https://ncbi.nlm.nih.gov/pubmed/22406090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2012.02.020
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