Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies

Convection-enhanced delivery (CED) is a promising local delivery technique for overcoming the blood–brain barrier (BBB) and treating diseases of the central nervous system (CNS). For CED, therapeutics are infused directly into brain tissue and the drug agent is spread through the extracellular space...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kim, Jung Hwan, Astary, Garrett W., Kantorovich, Svetlana, Mareci, Thomas H., Carney, Paul R., Sarntinoranont, Malisa
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730263/
https://ncbi.nlm.nih.gov/pubmed/22532321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-012-0566-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id pubmed-3730263
record_format dspace
spelling pubmed-37302632013-09-01 Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies Kim, Jung Hwan Astary, Garrett W. Kantorovich, Svetlana Mareci, Thomas H. Carney, Paul R. Sarntinoranont, Malisa Ann Biomed Eng Article Convection-enhanced delivery (CED) is a promising local delivery technique for overcoming the blood–brain barrier (BBB) and treating diseases of the central nervous system (CNS). For CED, therapeutics are infused directly into brain tissue and the drug agent is spread through the extracellular space, considered to be highly tortuous porous media. In this study, 3D computational models developed using magnetic resonance (MR) diffusion tensor imaging data sets were used to predict CED transport in the rat ventral hippocampus using a voxelized modeling previously developed by our group. Predicted albumin tracer distributions were compared with MR-measured distributions from in vivo CED in the ventral hippocampus up to 10 μL of Gd-DTPA albumin tracer infusion. Predicted and measured tissue distribution volumes and distribution patterns after 5 and 10 μL infusions were found to be comparable. Tracers were found to occupy the underlying landmark structures with preferential transport found in regions with less fluid resistance such as the molecular layer of the dentate gyrus. Also, tracer spread was bounded by high fluid resistance layers such as the granular cell layer and pyramidal cell layer of dentate gyrus. Leakage of tracers into adjacent CSF spaces was observed towards the end of infusions. 2012-04-25 2012-09 /pmc/articles/PMC3730263/ /pubmed/22532321 http://dx.doi.org/10.1007/s10439-012-0566-8 Text en © 2012 Biomedical Engineering Society
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Kim, Jung Hwan
Astary, Garrett W.
Kantorovich, Svetlana
Mareci, Thomas H.
Carney, Paul R.
Sarntinoranont, Malisa
Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
description Convection-enhanced delivery (CED) is a promising local delivery technique for overcoming the blood–brain barrier (BBB) and treating diseases of the central nervous system (CNS). For CED, therapeutics are infused directly into brain tissue and the drug agent is spread through the extracellular space, considered to be highly tortuous porous media. In this study, 3D computational models developed using magnetic resonance (MR) diffusion tensor imaging data sets were used to predict CED transport in the rat ventral hippocampus using a voxelized modeling previously developed by our group. Predicted albumin tracer distributions were compared with MR-measured distributions from in vivo CED in the ventral hippocampus up to 10 μL of Gd-DTPA albumin tracer infusion. Predicted and measured tissue distribution volumes and distribution patterns after 5 and 10 μL infusions were found to be comparable. Tracers were found to occupy the underlying landmark structures with preferential transport found in regions with less fluid resistance such as the molecular layer of the dentate gyrus. Also, tracer spread was bounded by high fluid resistance layers such as the granular cell layer and pyramidal cell layer of dentate gyrus. Leakage of tracers into adjacent CSF spaces was observed towards the end of infusions.
author Kim, Jung Hwan
Astary, Garrett W.
Kantorovich, Svetlana
Mareci, Thomas H.
Carney, Paul R.
Sarntinoranont, Malisa
author_facet Kim, Jung Hwan
Astary, Garrett W.
Kantorovich, Svetlana
Mareci, Thomas H.
Carney, Paul R.
Sarntinoranont, Malisa
author_sort Kim, Jung Hwan
title Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
title_short Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
title_full Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
title_fullStr Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
title_full_unstemmed Voxelized Computational Model for Convection-Enhanced Delivery in the Rat Ventral Hippocampus: Comparison with In Vivo MR Experimental Studies
title_sort voxelized computational model for convection-enhanced delivery in the rat ventral hippocampus: comparison with in vivo mr experimental studies
publishDate 2012
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3730263/
https://ncbi.nlm.nih.gov/pubmed/22532321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10439-012-0566-8
_version_ 1799384877802455040

Registos relacionados