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The iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na(+)/I(−) symporter

Na(+)/I(−) symporter (NIS)-mediated active accumulation of I(−) in thyrocytes is a key step in the biosynthesis of the iodine-containing thyroid hormones T(3) and T(4). Several NIS mutants have been identified as a cause of congenital I(−) transport defect (ITD), and their investigation has yielded...

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Main Authors: Paroder, Viktoriya, Nicola, Juan P., Ginter, Christopher S., Carrasco, Nancy
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Company of Biologists 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3730242/
https://ncbi.nlm.nih.gov/pubmed/23690546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.120246
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