Diapocynin prevents early Parkinson’s disease symptoms in the Leucine-Rich Repeat Kinase 2 (LRRK2(R1441G)) transgenic mouse

The most prominent mechanism proposed for death of dopaminergic neurons in Parkinson’s disease (PD) is elevated generation of reactive oxygen/nitrogen species (ROS/RNS). Recent studies suggest that ROS produced during PD pathogenesis may contribute to cytotoxicity in cell culture models of PD. We hy...

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Autors principals: Dranka, Brian P., Gifford, Alison, Ghosh, Anamitra, Zielonka, Jacek, Joseph, Joy, Kanthasamy, Anumantha G., Kalyanaraman, Balaraman
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729885/
https://ncbi.nlm.nih.gov/pubmed/23721786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.05.034
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