A novel mitochondrially-targeted apocynin derivative prevents hyposmia and loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic mouse model of Parkinson’s disease

Recently, we demonstrated that dimeric apocynin prevented loss of motor function in the leucine-rich repeat kinase 2 (LRRK2(R1441G)) transgenic (tg) mouse (treated with 200 mg/kg, three times per week) [B.P. Dranka et al., Neurosci. Lett. 549 (2013) 57-62]. Here we extend those studies by treating L...

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Vydáno v:Neurosci Lett
Hlavní autoři: Dranka, Brian P., Gifford, Alison, McAllister, Donna, Zielonka, Jacek, Joseph, Joy, O’Hara, Crystal L., Stucky, Cheryl L., Kanthasamy, Anumantha G., Kalyanaraman, Balaraman
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4253647/
https://ncbi.nlm.nih.gov/pubmed/25263790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2014.09.042
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