Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model

Until now, ex vivo generation of CD34+ hematopoietic stem cells (HSCs) from human embryonic stem cells (hESCs) mostly involved use of feeder cells of non-human origin. While they provided invaluable models to study hematopoiesis, in vivo engraftment of hESC-derived HSCs remains a challenging task. I...

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Hauptverfasser: Kim, Jaehyup, Zanjani, Esmail D., Jeanblanc, Christine M., Goodrich, A. Daisy, Hematti, Peiman
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729638/
https://ncbi.nlm.nih.gov/pubmed/23612043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.04.003
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